id: 35098
Title: Advances in understanding immune response and tumor classification in mammary gland pathology in cats and dogs
Authors: Желавський М.
Keywords:
Date of publication: 2023-12-07 12:05:59
Last changes: 2023-12-07 12:05:59
Year of publication: 2023
Summary: Immune defense mechanisms play a crucial role in the development of reproductive pathology. Studies have demonstrated the migration of immune cells to the site of neoplasia initiation. Previous research has highlighted the prognostic value of tumor-infiltrating lymphocytes in breast cancer patients particularly in triple-negative breast cancer. Expression of various markers (CD3, CD4, CD8, CD20, CD56, FoxP3, CD68, and CD163) in tumor-infiltrating lymphocytes and associated macrophages can now be determined. The adaptive immune response, including B-lymphocytes (CD20+) and T-cells (CD3+), is crucial in opposing tumor development. CD8+ lymphocytes infiltrating the tumor are associated with better survival, while CD4+ T-helper 2 and FoxP3+ regulatory T-cells can promote immune escape. NK cells (CD56+) in the innate immune system can kill cancer cells. The aim of the was to carry out a scientific review of modern information resources, information from international symposia and conferences on the nomenclature and classification of breast tumors, as well as strategies for the treatment of oncopathology in cats and dogs.
URI: http://repository.vsau.vin.ua/repository/getfile.php/35098.pdf
Publication type: Доповідь конференції
Publication: Науково-практична конференція «Актуальні питання сьогодення та післявоєнного відновлення сільського господарства й екології: експертно-аналітичні складові формування продовольчої стратегії України» з нагоди 20-річчя УЛЯБП АПК НУБіП України. 2 жовтня 2023
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